Polycystic Ovary Syndrome
June 2018 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Polycystic Ovary Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Polycystic Ovary Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Polycystic Ovary Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Polycystic Ovary Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
Authors:Salamun V, Jensterle M, Janez A, Vrtacnik Bokal E
Institution:Division of Obstetrics and GynecologyDepartment of Human Reproduction vesna.j.salamun@gmail.com. Centre Ljubljana, Ljubljana, Slovenia. Centre Ljubljana, Ljubljana, Slovenia.
Journal:Eur J Endocrinol. 2018 Jul;179(1):1-11. doi: 10.1530/EJE-18-0175. Epub 2018 Apr 27.

2:The role of lifestyle changes in the treatment of polycystic ovary syndrome.
Authors:Smyka M, Grzechocinska B, Wielgos M
Institution:1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland. Poland. Poland.
Journal:Neuro Endocrinol Lett. 2018 Feb;38(8):521-527.

3:The Efficacy of 24-Month Metformin for Improving Menses, Hormones, and Metabolic Profiles in Polycystic Ovary Syndrome.
Authors:Yang PK, Hsu CY, Chen MJ, Lai MY, Li ZR, Chen CH, Chen SU, Ho HN
Institution:Department of Obstetrics and Gynecology, National Taiwan University Hospital Yunlin Branch, Douliu, Taiwan. Taipei, Taiwan. Taipei, Taiwan. University, Taipei, Taiwan. Taipei, Taiwan. Taipei, Taiwan.
Journal:J Clin Endocrinol Metab. 2018 Mar 1;103(3):890-899. doi: 10.1210/jc.2017-01739.

4:Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial.
Authors:Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ, Jahromi BN
Institution:Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Incubator, Shiraz University of Medical Sciences, Shiraz, Iran. University of Medical Sciences, Shiraz, Iran. Incubator, Shiraz University of Medical Sciences, Shiraz, Iran. University of Medical Sciences, Shiraz, Iran. Incubator, Shiraz University of Medical Sciences, Shiraz, Iran. Sciences, Shiraz, Iran. Shiraz University of Medical Sciences, Shiraz, Iran. Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Medical Sciences, Shiraz, Iran. Shiraz, Iran.
Journal:Phytother Res. 2018 Feb;32(2):276-283. doi: 10.1002/ptr.5970. Epub 2017 Dec 18.

5:Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial.
Authors:Moretti C, Guccione L, Di Giacinto P, Simonelli I, Exacoustos C, Toscano V, Motta C, De Leo V, Petraglia F, Lenzi A
Institution:Department of Systems' Medicine, Unit of Endocrinology, Section of Reproductive Endocrinology, "San Giovanni Calibita" Hospital, University of Rome Tor Vergata, Rome, Italy. Endocrinology, "San Giovanni Calibita" Hospital, University of Rome Tor Vergata, Rome, Italy. Endocrinology, "San Giovanni Calibita" Hospital, University of Rome Tor Vergata, Rome, Italy. Foundation for Health Research and Education, Rome, Italy. Vergata, Rome, Italy. of Rome "Sapienza," Rome, Italy. of Rome "Sapienza," Rome, Italy. of Siena, Siena, Italy. of Siena, Siena, Italy. I" Hospital, University of Rome "Sapienza," Rome, Italy.
Journal:J Clin Endocrinol Metab. 2018 Mar 1;103(3):824-838. doi: 10.1210/jc.2017-01186.

6:Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis.
Authors:Arentz S, Smith CA, Abbott J, Bensoussan A
Institution:National Institute of Complementary Medicine, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia. s.arentz@westernsydney.edu.au.; School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
Journal:BMC Complement Altern Med. 2017 Nov 25;17(1):500. doi: 10.1186/s12906-017-2011-x.

7:Fetal Growth and Birth Anthropometrics in Metformin-Exposed Offspring Born to Mothers With PCOS.
Authors:Hjorth-Hansen A, Salvesen O, Engen Hanem LG, Eggebo T, Salvesen KA, Vanky E, Odegard R
Institution:Department of Internal Medicine, Levanger Hospital, Levanger, Norway. University of Science and Technology, Trondheim, Norway. Science and Technology, Trondheim, Norway. University of Science and Technology, Trondheim, Norway. Trondheim, Trondheim, Norway. Science and Technology, Trondheim, Norway. Trondheim, Trondheim, Norway. Science and Technology, Trondheim, Norway. Trondheim, Trondheim, Norway. University of Science and Technology, Trondheim, Norway. Trondheim, Norway.
Journal:J Clin Endocrinol Metab. 2018 Feb 1;103(2):740-747. doi: 10.1210/jc.2017-01191.

8:Cardiometabolic Risk in PCOS: More than a Reproductive Disorder.
Authors:Torchen LC
Institution:Division of Endocrinology, Ann & Robert H Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Box 54, Chicago, IL, 60611, USA. LTorchen@luriechildrens.org. LTorchen@luriechildrens.org.
Journal:Curr Diab Rep. 2017 Nov 11;17(12):137. doi: 10.1007/s11892-017-0956-2.

9:Ovarian surgery for symptom relief in women with polycystic ovary syndrome.
Authors:Lepine S, Jo J, Metwally M, Cheong YC
Institution:Department of Obstetrics and Gynaecology, Capital and Coast District Health Board, Wellington, New Zealand.
Journal:Cochrane Database Syst Rev. 2017 Nov 10;11:CD009526. doi: 10.1002/14651858.CD009526.pub2.

10:Polycystic ovary syndrome throughout a woman's life.
Authors:Bellver J, Rodriguez-Tabernero L, Robles A, Munoz E, Martinez F, Landeras J, Garcia-Velasco J, Fontes J, Alvarez M, Alvarez C, Acevedo B
Institution:IVI-Valencia, University of Valencia, Valencia, Spain. jose.bellver@ivi.es.
Journal:J Assist Reprod Genet. 2018 Jan;35(1):25-39. doi: 10.1007/s10815-017-1047-7. Epub 2017 Sep 27.

11:Depression and Anxiety in Polycystic Ovary Syndrome: Etiology and Treatment.
Authors:Cooney LG, Dokras A
Institution:Department of Obstetrics and Gynecology, University of Pennsylvania, 3701 Market Street 8th Floor, Philadelphia, PA, 19146, USA. ADokras@obgyn.upenn.edu.
Journal:Curr Psychiatry Rep. 2017 Sep 20;19(11):83. doi: 10.1007/s11920-017-0834-2.

12:Combined oral contraceptives plus spironolactone compared with metformin in women with polycystic ovary syndrome: a one-year randomized clinical trial.
Authors:Alpanes M, Alvarez-Blasco F, Fernandez-Duran E, Luque-Ramirez M, Escobar-Morreale HF
Institution:DiabetesObesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.; DiabetesObesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain hectorfrancisco.escobar@salud.madrid.org.
Journal:Eur J Endocrinol. 2017 Nov;177(5):399-408. doi: 10.1530/EJE-17-0516.

13:Weight Management Interventions in Women with and without PCOS: A Systematic Review.
Authors:Kataoka J, Tassone EC, Misso M, Joham AE, Stener-Victorin E, Teede H, Moran LJ
Institution:Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska academy, University of Gothenburg, Box 430, 405 30 Gothenburg, Sweden. Josefin.Kataoka@vgregion.se. 461 73 Trollhattan, Sweden. Josefin.Kataoka@vgregion.se. Preventive Medicine, Monash University, Locked Bag 29, Clayton, VIC 3168, Australia. eliza.tassone@monash.edu. Preventive Medicine, Monash University, Locked Bag 29, Clayton, VIC 3168, Australia. marie.misso@monash.edu. Preventive Medicine, Monash University, Locked Bag 29, Clayton, VIC 3168, Australia. Anju.Joham@monash.edu.
Journal:Nutrients. 2017 Sep 8;9(9). pii: nu9090996. doi: 10.3390/nu9090996.

14:Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline.
Authors:
Institution:American Society for Reproductive Medicine, Birmingham, Alabama.
Journal:Fertil Steril. 2017 Sep;108(3):426-441. doi: 10.1016/j.fertnstert.2017.06.026.

15:Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial.
Authors:Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A
Institution:National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.; School of Women's and Children's Health, Level 1, Women's Health Institute, Royal Hospital for Women, University of New South Wales, Barker Street, Randwick, NSW, 2031, Australia.; School of Science and Health, Western Sydney University, Building 24, Locked Bag 1797, Penrith, NSW, 2751, Australia.
Journal:Phytother Res. 2017 Sep;31(9):1330-1340. doi: 10.1002/ptr.5858. Epub 2017 Jul 7.

16:Metabolic effect of obesity on polycystic ovary syndrome in adolescents: a meta-analysis.
Authors:Li L, Feng Q, Ye M, He Y, Yao A, Shi K
Institution:a Department of Gynecology and Obstetrics , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.; b Department of Biostatistics , Southern Medical University , Guangzhou , China.
Journal:J Obstet Gynaecol. 2017 Nov;37(8):1036-1047. doi: 10.1080/01443615.2017.1318840. Epub 2017 Jun 28.

17:Pelvic floor dysfunction and polycystic ovary syndrome.
Authors:Taghavi SA, Bazarganipour F, Allan H, Khashavi Z, Reisi N, Dosha N, Aghili F, Keramati M, Zahedi S, Aji-Ramkani A
Institution:a Fertility and Infertility Research Center, Hormozgan University of Medical Sciences , Bandar Abbas , Iran. Sciences , Bandar Abbas , Iran. Education, Middlesex University , London , UK. Abbas , Iran. Abbas , Iran. Abbas , Iran. Abbas , Iran. Abbas , Iran. Abbas , Iran.
Journal:Hum Fertil (Camb). 2017 Dec;20(4):262-267. doi: 10.1080/14647273.2017.1292003. Epub 2017 Feb 21.

18:Insulin sensitizers in adolescents with polycystic ovary syndrome.
Authors:LE TN, Wickham EP Rd, Nestler JE
Institution:Division of Endocrinology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA - trang.le@vcuhealth.org. Commonwealth University, Richmond, VA, USA - trang.le@vcuhealth.org. University, Richmond, VA, USA. Commonwealth University, Richmond, VA, USA. University, Richmond, VA, USA.
Journal:Minerva Pediatr. 2017 Oct;69(5):434-443. doi: 10.23736/S0026-4946.17.04976-3. Epub 2017 May 11.

19:Extension of the clomiphene citrate stair-step protocol to gonadotropin treatment in women with clomiphene resistant polycystic ovarian syndrome.
Authors:Horowitz E, Levran D, Weissman A
Institution:a IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center , Holon , Israel. , Holon , Israel. , Holon , Israel.
Journal:Gynecol Endocrinol. 2017 Oct;33(10):807-810. doi: 10.1080/09513590.2017.1320381. Epub 2017 Apr 28.

20:The diagnosis and lived experience of polycystic ovary syndrome: A qualitative study.
Authors:Tomlinson J, Pinkney J, Adams L, Stenhouse E, Bendall A, Corrigan O, Letherby G
Institution:Pool Health Centre, Cornwall, UK. Chelmsford, UK.
Journal:J Adv Nurs. 2017 Oct;73(10):2318-2326. doi: 10.1111/jan.13300. Epub 2017 May 15.

21:Is cardiovascular risk in women with PCOS a real risk? Current insights.
Authors:Papadakis G, Kandaraki E, Papalou O, Vryonidou A, Diamanti-Kandarakis E
Institution:STEPS Stoffwechselzentrum, Biel/Bienne, Switzerland. Hospital, Athens, Greece. Hospital, Athens, Greece - e.diamanti.kandarakis@gmail.com.
Journal:Minerva Endocrinol. 2017 Dec;42(4):340-355. doi: 10.23736/S0391-1977.17.02609-8. Epub 2017 Jan 31.

22:Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
Authors:Ahmadi S, Jamilian M, Karamali M, Tajabadi-Ebrahimi M, Jafari P, Taghizadeh M, Memarzadeh MR, Asemi Z
Institution:a Department of Gynecology and Obstetrics, School of Medicine , Iran University of Medical Sciences , Tehran , Iran. University of Medical Sciences , Bushehr , Iran. Obstetrics, School of Medicine , Arak University of Medical Sciences , Arak , Iran. of Medical Sciences , Tehran , Iran. branch , Tehran , Iran. branch , Arak , Iran. University of Medical Sciences , Kashan , Iran. University of Medical Sciences , Kashan , Iran.
Journal:Hum Fertil (Camb). 2017 Dec;20(4):254-261. doi: 10.1080/14647273.2017.1283446. Epub 2017 Feb 1.

23:Maternal Polycystic Ovary Syndrome and Risk for Attention-Deficit/Hyperactivity Disorder in the Offspring.
Authors:Kosidou K, Dalman C, Widman L, Arver S, Lee BK, Magnusson C, Gardner RM
Institution:Centre for Epidemiology and Community Medicine, Stockholm County Council, Karolinska Institutet, Stockholm, Sweden; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.; Division of Public Health Epidemiology, and Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, Pennsylvania; A.J. Drexel Autism Institute, Philadelphia, Pennsylvania.; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. Electronic address: renee.gardner@ki.se.
Journal:Biol Psychiatry. 2017 Nov 1;82(9):651-659. doi: 10.1016/j.biopsych.2016.09.022. Epub 2016 Oct 6.

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