Chronic Lymphocytic Leukemia
September 2018 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Lymphocytic Leukemia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Lymphocytic Leukemia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Lymphocytic Leukemia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Lymphocytic Leukemia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:The Frequency and Prognostic Value of Neutrophilia in Chronic Lymphocytic Leukemia.
Authors:Levy I, Vadasz Z, Polliack A, Tadmor T
Institution:Internal Medicine B Department, Bnai-Zion Medical Center, Haifa, Israel. Israel. School, Jerusalem, Israel. tamar.tadmor@b-zion.org.il.
Journal:Anticancer Res. 2018 Aug;38(8):4731-4734. doi: 10.21873/anticanres.12780.

2:Diagnosis of Richter transformation in chronic lymphocytic leukemia: histology tips the scales.
Authors:Federmann B, Mueller MR, Steinhilber J, Horger MS, Fend F
Institution:Institute of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tubingen, University of Tubingen, Liebermeisterstr. 8, 72076, Tubingen, Germany. falko.fend@med.uni-tuebingen.de.; Department of Hematology and Oncology, University Hospital and Comprehensive Cancer Center Tubingen, University of Tubingen, 72076, Tubingen, Germany.; Department of Radiology, University Hospital and Comprehensive Cancer Center Tubingen, University of Tubingen, 72076, Tubingen, Germany.
Journal:Ann Hematol. 2018 Oct;97(10):1859-1868. doi: 10.1007/s00277-018-3390-x. Epub 2018 Jun 12.

3:CLL2-BXX Phase II trials: sequential, targeted treatment for eradication of minimal residual disease in chronic lymphocytic leukemia.
Authors:Cramer P, von Tresckow J, Bahlo J, Engelke A, Langerbeins P, Fink AM, Fischer K, Wendtner CM, Kreuzer KA, Stilgenbauer S, Bottcher S, Eichhorst B, Hallek M
Institution:Department I of Internal Medicine & Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital Cologne, Cologne, Germany.; Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases & Tropical Medicine, Klinikum Schwabing, Munich, Germany.; Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany.; Department III of Internal Medicine, University Hospital Rostock, Rostock, Germany.; Department II of Internal Medicine, Campus Kiel, University of Schleswig-Holstein, Kiel, Germany.
Journal:Future Oncol. 2018 Mar;14(6):499-513. doi: 10.2217/fon-2017-0442. Epub 2018 Feb 21.

4:Elevated absolute NK cell counts in peripheral blood predict good prognosis in chronic lymphocytic leukemia.
Authors:Wang WT, Zhu HY, Wu YJ, Xia Y, Wu JZ, Wu W, Liang JH, Wang L, Fan L, Li JY, Xu W
Institution:Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China. xuwei10000@hotmail.com.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China. xuwei10000@hotmail.com.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China. xuwei10000@hotmail.com.
Journal:J Cancer Res Clin Oncol. 2018 Mar;144(3):449-457. doi: 10.1007/s00432-017-2568-2. Epub 2018 Jan 3.

5:Cost-utility analysis of idelalisib in combination with rituximab in relapsed or refractory chronic lymphocytic leukaemia.
Authors:Casado LF, Hernandez JA, Jarque I, Echave M, Casado MA, Castro A
Institution:Haematology and Hemotherapy Service, Hospital Virgen de la Salud, Toledo, Spain. Madrid, Spain.
Journal:Eur J Haematol. 2018 Mar;100(3):264-272. doi: 10.1111/ejh.13007. Epub 2018 Jan 17.

6:Association between immunoglobulin heavy-chain variable region mutational status and isolated favorable baseline genomic aberrations in chronic lymphocytic leukemia.
Authors:Sandoval-Sus JD, Chavez JC, Dalia S, Naqvi SMH, Talati C, Nodzon L, Kharfan-Dabaja MA, Pinilla-Ibarz J
Institution:a H. Lee Moffitt Cancer Center and Research Institute, University of South Florida , Tampa , FL , USA. Institute , Tampa , FL , USA. and Research Institute , Tampa , FL , USA. Florida , Tampa , FL , USA. Institute , Tampa , FL , USA. and Research Institute , Tampa , FL , USA. Institute , Tampa , FL , USA.
Journal:Leuk Lymphoma. 2018 Jan;59(1):59-68. doi: 10.1080/10428194.2017.1323271. Epub 2017 Jun 22.

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What Our Customers Are Saying...

"I was recently diagnosed with CLL and searched all over the Web for information. I found the MediFocus Guidebook on Chronic Lymphocytic Leukemia to be a very useful resource. The information about chemotherapy was most important to me as well as recent studies concerning general treatments for this condition. The most valuable information was contained in the extensive references listed which were easy to access with a simple 'mouse' click. You are welcome to use my name as a reference."
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Coedpoeth, United Kingdom



  
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